Dermial is designed to improve the effectiveness of standard HA, Daniel Martínez Puig, head of human and animal health research and development, told NutIngredients that the new Studies have shown visible improvements in aging skin.
The first human clinical trial conducted with this ingredient investigated the effects of 60 mg of Dermial per day or a placebo over 12 weeks in 60 women between the ages of 35 and 65.
Although the results have not yet been published, they suggest that the supplement improves skin hydration and reduces wrinkles.
healthy aging skin
Hyaluronic acid is attracting attention from consumers and industry. According to the FMCG Gurus Healthy 2022 Aging Skin Report, 34% of consumers associate hyaluronic acid ingredients with skin health, and data from Future Market Insights predicts that the hyaluronic acid personal care products market will grow from 2023 to 2033. It is predicted to grow by 8% during that period.
Naturally occurring polysaccharides are present in the dermis and epidermis of the skin, and their main function is to bind water to collagen, trapping water and keeping the skin hydrated.
Hyaluronic acid levels decline with age, which can lead to loss of elasticity, increased dryness and fragility, suggesting the need for supplements, Martinez-Puig said, explaining that hyaluronic acid supplements are absorbed in the intestine and accumulate in connective tissues, including skin.
The dermis contains high concentrations of HA (60-75%), as well as other components such as sulfated glycosaminoglycans and collagen, which work synergistically to improve the results of standard HA supplements. designed to improve. Previous studies have shown that Dermial can improve type I collagen by 48% compared to fermentation-derived HA.
As Martinez Puig explained, the ingredient is being positioned as appealing to consumers interested in the growing “ageless” category.
“The results we saw are consistent with the anti-aging trend of increased wrinkles, decreased skin hydration, and increased dryness, similar to the aging process,” he said. “But our results show that there is a real balance in the aging process.”
skin results
Martinez Puig previewed the latest research results, noting that daily dermal supplement administration increased skin brightness by 20% in 6 weeks and 34% in 12 weeks.
A statistically significant difference was also observed in wrinkle reduction between the Dermial and placebo groups after 6 weeks. Additionally, stratum corneum (outermost layer of the epidermis) hydration, dryness, skin temperature, and erythema index (skin redness) were significantly improved in the dermal group at 6 weeks compared to baseline.
Participants’ perceptions also improved, as noted by Martinez-Puig, consumer satisfaction was significantly higher for women who took the supplement (69%) compared to the placebo group (42%) .
previous in vitroStudies have shown that, compared to standard HA, Dermial improves collagen type I synthesis, supports human dermal fibroblast (HDF) cell proliferation at a significantly higher rate, and increases HEK cell migration. It turns out.
“This study shows that Dermial can bring regenerative activity to the dermal and epidermal layers of the skin and support dermal maintenance and functionality better than standard HA,” said Martinez-Puig. .
“This human clinical trial has demonstrated superior efficacy in terms of collagen I production.”
journal: Journal of Investigative Dermatology, 2024.(in press).
Author: Galvez-Martin, P et al.
