In a new study, experts warn against indiscriminate use of anti-malarial plants by men as they can affect fertility levels. They listed common malaria herbal remedies that are harmful to male fertility.
Researchers looked at 28 different anti-malarial plants and found that many men consume herbal preparations containing these plants in large amounts or in excess because they believe they are safe, but when male contraception is not desired. He said it is better to refrain from using it.
Many herbal medicines for malaria are prepared using the leaves, bark, or roots of at least one of these medicinal plants. Many people consume these antimalarial herbal remedies in large quantities or in excess, making them vulnerable to the anti-reproductive effects of such herbal remedies due to their male factors.
Globally, male factors account for more than 50% of infertility cases. There are growing health concerns worldwide. In Nigeria, researchers are concerned that over-reliance on anti-malarial plant treatments may be contributing to male infertility.
This review of commonly used antimalarial phytotherapy that has been experimentally verified to have anti-reproductive effects due to male factors, published in the Journal of Complementary and Integrative Medicine in 2019, includes: Kayode Ezekiel Adewole and Alfred Francis Attah participated.
The 28 anti-malarial plants include Abrus precatorius (Oju Ologbo in Yoruba or Damalu zaya in Hausa), Garlic, Anona senegalensis (Abo in Yoruba, Gwandan Daji in Hausa, Ubulu Rocha in Igbo); Alstonia booney (Yoruba stool wood or ahun), neem leaves and seeds, Bridelia ferruginea (Kimi Hausa, Iralodan in Yoruba, Ola in Igbo), Cajanus cajan (fio fio in Igbo, waken- in Hausa) masar (Yoruba otili), pawpaw leaves and roots, Chromolaena odorata (Christmas) bush or achintrataku (Yoruba), Tithonia diversifolia (Mexican sunflower), Crospteryx febrifuga (Hausa Kasin akuya).
Other plants include Cryptolepis sanginolenta (Akpaoku in Igbo and Gangamau in Hausa), Turmeric, Silicodiscus gabunensis (Okan), Ficus toningi (wild fig), Kaya senegalensis (Mahogany in English), Lipia mulch Flora (bush tea or “Effinlin Ajace”), Morinda, etc. Lucida (Uluwo), Nauclea latifolia (Egbo Egbesi of Yoruba, Uburu Inu of Igbo, Tabasiya of Hausa), Scented Leaf, Phyllanthus amarus (Eyin Orobe of Yoruba), Piclarima nitida (Male of Igbo) Igwe, Yoruba Erin), Quasiaamara (bitter tree), Sphenocentrum jollyanum (Yoruba Akerejupon or Igbo Ibon Ison), bitter leaf, Solenostemon monostachyus (Ibibio Ntorikwot and Yoruba Olojogbodu).
The male-factor infertility effects of these plants include reducing sperm quality, regulating reproductive hormone levels, and inducing lipid peroxidation.
For example, consuming garlic for a month had a negative effect on testosterone secretion and sperm production, according to this review. Furthermore, consumption of garlic powder has been shown to halt sperm production in rats after 70 days of administration.
Similarly, extracts of the roots and leaves of pawpaw extract made with water or alcohol can reduce sperm count, increase the percentage of abnormal sperm, reduce testosterone levels in the blood, and reduce the lining of the testicles. It seriously destroyed the cells.
Administration of aqueous extract of Annona senegalensis leaves for 21 days significantly decreased testicular body weight ratio and total protein content in testes, increased cholesterol, glycogen, and malondialdehyde concentrations in testes, and degenerated seminiferous tubules. It has been reported that. In rats.
Another study found that consumption of water wood ash extract derived from the whole plant significantly reduced sperm motility, sperm count, live/dead sperm, and increased abnormal sperm cells.
Additionally, administration of ethanol-soaked neem stem bark extract for 10 weeks reduced the weight of testes, seminal vesicles, and epididymis in laboratory rats. The extract altered the rats’ sperm count, morphology, and viability, caused a decrease in serum testosterone and luteinizing hormone, and rendered the rats unable to impregnate female rats during the experimental period.
Similarly, ingestion of bitter leaf extract soaked in ethanol for 56 days has been shown to cause testicular toxicity in rats. Administration of its aqueous extract for 15 days has been reported to adversely affect sperm parameters (sperm count, morphology, and viability) and cause testicular degeneration.
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