There are hundreds of anti-aging serums on the market promising rejuvenating results. But when you narrow it down to serums that are fragrance-free, dermatologist-approved, and backed by multiple clinical studies, the options narrow. DefenAge 8-in-1 BioSerum meets all these criteria and more. Praised by skin care experts for its unique mechanism of action and powerful key ingredients, it’s proven to be effective in minimizing many signs of aging.
And the product is so multi-tasking, offering the benefits of eight serums in one formula, hence the name. “Apart from sunscreen, many patients want a one-step solution, and that’s how it should be,” says Dr. Angela Bowers, a dermatologist in Southlake, Texas. As a busy mom of two, I agree with Dr. Bowers that I want a one-step solution. When I first tried Bio Serum a few years ago, I was blown away by its moisturizing, brightening, and smoothing effects. Anti-aging was my goal then, and it remains so now in my mid-30s.
And we still love the silky, non-greasy texture, the fragrance-free nature of it, and of course, the strong science backing up its effectiveness. This product leaves skin super smooth and visibly hydrated, while the active ingredients work to keep skin looking as healthy and youthful as possible. Read on to learn all about the exciting properties of this revolutionary rejuvenating serum, with the help of leading dermatologists.
Featured Experts
Who is this anti-aging serum best for?
Natalie M. Curcio, MD, a dermatologist in Nashville, Tennessee, says this serum is perfect for anyone over 45 who wants to improve the signs of aging. “Signs of aging include uneven skin tone, dullness, fine lines, sagging skin, pigmentation, enlarged pores, redness, and inflammation,” explains Dr. Curcio. “All of these signs of skin damage that occur with age can be addressed and improved with this serum.” But you can also use the serum at a younger age to help prevent aging, as Dr. Curcio did. “With good skin care before the signs of aging become visible, you may be able to delay or prevent a lot of aging by years. In my opinion, anyone who wants to improve their appearance can benefit from this serum, and from DefenAge skin care in general.”
This anti-aging serum can be used on all skin types, adds Dr. Bowers, “which is one of the great things about it.” It’s gluten-free, fragrance-free, and non-comedogenic, so it won’t clog pores. It’s so light it feels like you’re not putting anything on your skin.
Main Ingredients Bioceram
The key ingredient is the scientific term for “Defensin Molecules.” This anti-aging serum contains the highest concentration of Defensin Molecules of any skincare product. Two defensins in particular, Alpha Defensin 5 and Beta Defensin 3, are exclusive to DefenAge and actively rejuvenate the skin. It also acts as an effective alternative to Retinol, making this serum suitable for sensitive skin types.
“A lot of older patients have pretty dry skin and can’t tolerate the side effects of retinoids, like peeling and dryness,” says Dr. Bowers. “This is a great alternative to retinol for them, but when used in conjunction with a retinoid, it works synergistically.” Other key ingredients in the formula include antioxidants, niacinamide, hydrating hyaluronic acid, DNA repair enzymes, peptides, and a blend of soothing natural actives.
How exactly do defensins work?
“Defensin molecules, or age-repair defensins, activate the body’s master skin cells to create new skin,” says Dr. Curcio, “which promotes a more youthful, rejuvenated appearance. These age-repair defensins promote cell renewal while addressing fine lines, wrinkles, uneven skin, sagging skin, excess pigment, inflammation, and large pores.”
To better understand the mechanisms behind defensin molecules, let us look at the regenerative biology of wound healing. “Defensins trigger a skin regeneration response similar to what our bodies do when healing wounds. The skin in a healed wound will always be younger than the skin around it. This is because our body activates stored or dormant cells to heal the wound. In other words, the body creates new, younger skin to heal the wound,” says Dr. Curcio. Defensins activate the same mechanism in our bodies. “So every time you apply defensins to your skin, you activate your body to create new, younger skin that’s free of blemishes,” continues Dr. Curcio. “I consider defensins the biggest breakthrough in cosmetic skincare since the discovery of retinoids.”
Dr. Bowers adds, “Using defensins has also been shown to activate fibroblasts, stimulate collagen and elastin, and promote the body’s natural secretion of natural growth factors.”
What clinical studies show
When it comes to powerful skin care products, NewBeauty editors are always on the lookout for clinical studies to back up big claims. Amazingly, the 8-in-1 Bio Serum and its key defensin-based ingredients have been tested in 11 peer-reviewed clinical studies. Journal of Drugs in Dermatologyreaffirms the effectiveness of serums as an anti-aging rejuvenating solution.
“We conducted a multi-center, prospective clinical trial using DefenAge 8-in-1 Bio Serum in combination with 3D Radiance Eye Cream in patients ages 45 to 80,” explains Dr. Curcio. “Patients applied the products twice daily around the eyes and after three months experienced statistically significant improvements in periorbital wrinkles and sun damage compared to baseline. Improvements were seen in all aspects of skin quality, including wrinkles, sagging, hyperpigmentation, redness, skin texture, and radiance. The combination of Bio Serum and Eye Cream is safe and effective for treating wrinkles around the eyes.” Dr. Bowers says that since he began personally recommending and using the product about seven years ago, all of his patients have seen a noticeable improvement in their skin.
The range of defensin molecules in our Age Repair Defensin Complex has also been tested in independent clinical safety studies, all of which have been conducted in the United States and overseen by an independent Institutional Review Board.
How to use this beauty essence
Apply to clean skin after cleansing. If you’re also using DefenAge’s 24/7 Barrier Balance Cream, apply that first, then apply Bio Serum. “It may seem counterintuitive at first, because we’re trained to apply serums,” says Dr. in front “There’s a difference between creams,” says Dr. Curcio, “but I’d apply a moisturizing cream first, which also contains Age Repair Defensins, to hydrate the skin, and then apply the rejuvenating 8-in-1 Bio Serum second, which has the highest concentration of defensins. The Bio Serum closes the skin’s tight junctions to prevent moisture loss, so the cream becomes a more effective moisturizer without feeling heavy.”
If you’re also applying another serum, like a vitamin C or retinol-based serum, apply it first before the 8-in-1 Bio Serum, says Dr. Curcio. “If you apply it on top of the Bio Serum, it won’t absorb into the skin as well.” And as with the rest of your skincare routine, be sure to apply sunscreen as your final step before applying makeup.
This anti-aging serum can be used on the neck, décolleté, back of the hands, and anywhere else you’re showing signs of aging. I’ve also heard doctors recommend it for wrinkled skin on the arms and knees. Don’t be surprised if you see this serum in your dermatologist’s office. Many doctors extol BioSerum’s skin-rejuvenating properties and apply it after treatments like microneedling to maximize results, or recommend using it to prep the skin before fillers or laser treatments.
Expected Results from Using DefenAge BioSerum
Most people start to notice a change in their skin’s texture in just two weeks, with more visible changes occurring after four to eight weeks. “Friends, family, and coworkers will comment on how much smoother and more radiant your skin looks,” says Dr. Curcio. “As fine lines, wrinkles, sagging skin, pigmentation, pore size, and inflammation all continue to improve, you’ll really see what we call an ‘improved overall appearance.'”
“The patient is the best judge,” says Dr. Bowers. “I’ve been in the business for over 20 years and have tried all kinds of skin care products. Of all the new skin care products we’ve offered, DefenAge has by far gotten the most impressive patient feedback.”
Price / Where to buy
DefenAge 8-in-1 BioSerum comes in a variety of sizes to suit all tastes – the two most popular are the full-size 30ml version ($246) and the mega-size 50ml ($264), but there’s also a 10ml version ($75) that gives you a two-week supply, and a trial size ($17) that gives you a two-to-three day supply.
Buy Now – $264
