Preclinical studies have shown that compounds in plants can modulate which genes are converted into proteins in cells, potentially reducing long-term COVID-19 infections and immune and aging-related conditions, including Alzheimer’s disease. It has been shown that it may be effective for improvement.
“Managing aging is difficult due to its progressive and irreversible nature and age-related comorbidities,” write Sujit Nehru (Phytoveda, Mumbai, India) and colleagues.
They suggest that the aging process could be slowed down by “recent advances, including dietary supplement interventions that can modulate the transcriptional activity of various genes involved in aging and age-related complications.” Masu.
Addressing the characteristics of aging
As the world’s population ages, age-related conditions are expected to increase in the coming decades, making preventive strategies important, study authors said.
“Aging is a complex process that affects various body organs and has effects at the cellular and molecular level,” Dr. Nair told NutIngredients, adding that the aging process involves shortening of telomeres and cell function. He added that a series of biological “signatures” are involved, including epigenetic changes that impair the development of cancer. Function of cells.
Winter cherry blossoms, also known as ashwagandha Withania somnifera,is an evergreen shrub that grows in the Middle East, Africa, and Asia, and its active ingredients include withanolides such as withaferin A, withanolides, and withanone. The plant is a common ingredient in traditional medicine with antioxidant and immunomodulatory properties and may have a role in “regulating changes in RNA levels associated with aging,” Nair said.
WithaniaThe review notes that it has already shown efficacy against aging-related symptoms in human cell culture studies. For example, the plant’s action on inflammatory markers makes it a potential tool to treat long-term COVID-19 infections. It also reduces neuroinflammation and neurodegeneration, and may slow the progression of Alzheimer’s disease. Other conditions that may be addressed by this plant and its ingredients include gastrointestinal ulcers, breast cancer, and asthma.
work in progress
Withaniahas been commercialized as a dietary supplement in various forms, including PhytoVeda. However, research into its role in promoting healthy aging is in its infancy.
“Clinical trials have attempted to demonstrate, to some extent, that benefit. Withania somnifera“We primarily aim to identify biomarkers of response, such as inflammatory biomarkers and markers of stress, anxiety, and endurance,” Nair said, adding, “However, results from clinical studies are limited. “The results of these trials have rarely been peer-reviewed.” ”, highlighting the uncertainty of their situation.
Nile’s team is currently conducting clinical trials on the aging plant, with results expected in the coming months.
In addition to generating scientific evidence, an important mission is to ensure batch-to-batch quality of the manufacturing process. Another priority for the field is to elucidate the precise biological mechanisms behind bacterial effects. WithaniaAbout the characteristics of aging.
“The main challenge in using nutritional supplements is to discover a ‘panacea’ for all aspects of the aging process and precisely adjust the dosage and duration of nutritional supplements to enable healthy aging.” “That’s what we do,” Nile said.
As this roadmap progresses, considering the regulation of key RNA markers in aging and inflammatory pathways. WithaniaThe review concluded with the goal of achieving healthy aging.
sauce: Frontiers of nutrition
2024, 11:1370951, doi: https://doi.org/10.3389/fnut.2024.1370951
“Latest findings on the transcriptional role of the nutraceutical Withania somnifera in inflammation and aging”
Author: Praful Saha et al.
