Research Protocol Article
Front. Endocrinology.
Reproduction Terms
Volume 15 – 2024 |
doi: 10.3389/fendo.2024.1380444
Tentatively approved
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Shandong University of Traditional Chinese Medicine (Jinan, China)
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Background: Decreased ovarian reserve (DOR) refers to a decrease in the number and quality of oocytes in the ovarian cortex, and is a degenerative disease of the reproductive system that may further develop into premature ovarian failure. There are few acupuncture studies for DOR and it is still in the exploratory stage. Methods/Design: This study is a real-life case registry study. Subjects were divided into a basic treatment group combined with fertility acupuncture and a basic treatment group according to whether they received fertility acupuncture treatment or not. A total of 1221 DOR patients were enrolled and treated for 12 weeks. The proportion of patients with an improvement of ≥30% in anti-Müllerian hormone (AMH) was evaluated at the end of the 12th week. Secondary outcomes included ovarian follicle count (AFC), modified Kupperman scale, basal FSH level, LH level, FSH/LH ratio, positive pregnancy, clinical pregnancy, early spontaneous abortion, ongoing pregnancy, and ectopic pregnancy. Discussion: This study aims to provide clinical evidence and theoretical support for the treatment of DOR with conceptus canal acupuncture, and to guide and improve the efficacy of acupuncture. Trial registration: Acupuncture Clinical Trial Registry ChiCTR2400080471. Registered on January 30, 2024.
keyword:
Decreased ovarian reserve, Acupuncture, Multicenter, Fertility vasculature, Study protocol
received:
February 1, 2024;
approved:
July 25, 2024.
Copyright:
© 2024 Zhang, Sun, Zhang, Mou, Xia, Du and Ma. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY). Use, distribution, or reproduction in other forums is permitted, provided the original author(s) or licensors are credited and the original publication in this journal is cited in accordance with accepted scholarly practice. Any use, distribution, or reproduction not in accordance with these terms is not permitted.
* correspondence:
Zhang Xiaoyu, Shandong University of Traditional Chinese Medicine, Jinan, China
Disclaimer:
All claims made in this article are those of the authors themselves and do not necessarily represent those of their institutions, publishers, editors, or reviewers. Products evaluated in this article, or claims made by their manufacturers, are not endorsed or approved by the publishers.
