Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that affects millions of people worldwide. Bowel resection is a common surgical intervention for his IBD patients and has a significant impact on quality of life. Although the anti-inflammatory and immunomodulatory effects of vitamin D have been studied, its association with intestinal resection risk in IBD remains unclear. Recent research has International Journal of Surgery By Dan Lingtao and colleagues.
This longitudinal cohort study analyzed data from 5,474 patients with IBD from the UK Biobank. Serum 25-hydroxyvitamin D [25(OH)D] Levels were measured and bowel resection events were recorded via national inpatient data. Cox proportional hazards regression and restricted cubic spline analysis were used to assess the association between serum 25(OH)D levels and intestinal resection risk.
The main findings of the study are:
-
Over a mean follow-up of 13.1 years, 513 bowel resection events were recorded.
-
Participants with non-deficient vitamin D levels were less likely to undergo intestinal resection in IBD (HR 0.72, 95% CI 0.59-0.87, P=0.001) and Crohn’s disease (CD, HR 0.74, 95% CI 0.56-0.98, P). The risk was significantly reduced. =0.038) and ulcerative colitis (UC, HR 0.73, 95% CI 0.57-0.95, P=0.020) compared to patients with vitamin D deficiency.
-
Comparing the extreme quintiles of 25(OH)D levels, there was a 34% reduced risk of bowel resection in IBD (95% CI 11%-51%, P=0.007) and a 46% reduced risk of UC. (95% CI 19%). -64%, P=0.003), no significant association with CD.
-
A linear dose-response relationship was observed, showing a consistent decrease in intestinal resection risk with increasing serum 25(OH)D levels (all P nonlinearity > 0.05).
This study highlights the importance of adequate vitamin D levels in reducing the risk of intestinal resection in patients with IBD. Although this association was significant in UC, further research is needed to elucidate the relationship in CD. Vitamin D deficiency has emerged as a risk factor for intestinal resection, suggesting potential as a predictive indicator of surgical events in IBD.
This study concluded that elevated serum 25(OH)D levels are independently associated with a lower risk of bowel resection in IBD, particularly UC. Addressing vitamin D deficiency may provide a preventive strategy for surgical intervention in patients with IBD.
reference:
