Study reveals anti-aging role of vitamin D and vitamin D receptors in Drosophila midgut model

A new research paper has been published in . aging (Listed as “Aging (Albany, NY)” in MEDLINE/PubMed and “Aging-USA” in Web of Science) Volume 16, Issue 3, titled “Vitamin D and the Vitamin D Receptor in Aging “Preventive effect” Drosophila Midgut. ”

Adult stem cells are crucial for maintaining tissue homeostasis, and their functional decline is influenced by the cell niche environment and is associated with aging and related diseases. Decreased levels of vitamin D and its receptors associated with aging and cancer are well documented in human clinical studies. However, the mechanisms by which the vitamin D/vitamin D receptor (VitD/VDR) pathway contributes to antiaging and increases life expectancy are poorly understood.In this new study, researchers Park Johnson, Na Hyun Jin and Kim Young Jin Researchers from Busan National University and the Korea Institute of Food Research aimed to elucidate the protective role of the vitamin D/vitamin D receptor pathway in differentiated enterocytes (ECs) in the aging of intestinal stem cells (ISCs). .

“This study aimed to determine the protective role of VitD/VDR in differentiated ECs during ISC aging using adult cells. Drosophila A model of the intestines. ”

By utilizing a well-established system, Drosophila Using a midgut model of stem cell aging biology, researchers reveal that knockdown of vitamin D receptors in ECs induces ISC proliferation, EC death, ISC senescence, and enteroendocrine cell differentiation. I made it. Furthermore, age- and oxidative stress-induced increases in ISC proliferation and centrosome amplification were attenuated by vitamin D treatment. In conclusion, this study provides direct evidence for the anti-aging role of the VitD/VDR pathway involved in protecting ECs during aging and explores the molecular mechanisms underlying the promotion of healthy aging. provides valuable insight. Drosophila.

“Our findings suggest direct evidence of an anti-aging role for the vitamin D/vitamin D receptor pathway and provide insight into the molecular mechanisms underlying healthy aging. Drosophila. ”