Dr. Andrea Fuso, a 15-year collaborator with Gnosis by Lesaffre, focuses on cognitive health and has expanded her research to include vitamin K2 in neurological support. published new research highlighting the role of K2.
The study, published in Cells, identifies a link between K2 supplements and neurodegeneration and neuroinflammation, pointing to K2’s potential role as a supplement to support healthy brain and cognitive function.
Supporting neurological function with K2
In new research1Fuso, an associate professor of clinical biochemistry and molecular biology at the Department of Experimental Medicine at Sapienza University in Rome, tested K2 as menaquinone-7 (reduced form) along with K2-menaquinone-4 in a model of neuroblastoma cells. We decided how it would be formed. The amount of K2 influences the expression of genes involved in neurodegeneration and neuroinflammation.
Administration of vitamin K2 creates a favorable balance of activity, decreasing the expression of genes associated with neurodegeneration (PSEN1 and BACE1) and neuroinflammation (IL-1β and IL-6), while at the same time upregulating genes that protect against amyloid. It has been found that controlling nerve function can be supported. Formation (ADAM10 and ADAM17).
Additionally, the research team also profiled the DNA methylation patterns of the genes and found a correlation between hypermethylation and downregulation of PSEN1, IL-1β, and IL-6.
This new mechanistic study supports previous studies that discussed a role for K2 in Alzheimer’s disease through dysbiosis of the gut microbiome.[2]
Summarizing the study, Dr. Fuso commented: “Our early research highlighted the role of B vitamins and SAMe as dietary factors linking nutrition and epigenetic regulation of brain disease. Introducing research on K2.
“After 15 years of collaboration with Dr. Fuso and his team, there is a growing body of evidence demonstrating how naturally derived ingredients can be used. [e.g., SAMe and vitamin K2 (as MK-7)] It has a significant impact on brain function and cognitive activity. ” Jean-François Jeanne, Demonstration and Applications Manager at Gnosis by Lesaffre said:
reference
1 Fuso et al. “Comparing amyloidogenic and neuroinflammatory molecular pathways using menaquinone”
