This is based on the research of Dr. CiLab’s new and improved 377VC Radiance Serum.
This serum was shown to improve transient UV-induced hyperpigmentation and skin whitening by 6 times over 7 days over a blank control group.
An 8-week clinical study showed significant improvement in solar lentigines and acne PIH, and the targeted dark spot whitening effect was maintained for 2 weeks after participants stopped using the product.
The latest formula combines phenylethyl resorcinol, antioxidants, and soothing ingredients to reduce the appearance of hyperpigmentation and prevent new age spots from forming.
Ian Charlton, Kenvue’s senior director of research and development, skin health and beauty, said: Cosmetic Design-AsiaUnlike traditionally popular whitening ingredients such as vitamin C, glutathione, alpha-bisabolol, and niacinamide, phenylethyl resorcinol “You can better maintain the brightness of your skin.”
“Phenylethyl resorcinol is one of the most effective ingredients that targets the root cause of melanin production. It acts as a competitive inhibitor of tyrosinase, blocking the production of new melanin in melanocytes.”he explained.
“The main cause of hyperpigmentation is melanin production. Phenylethylresorcinol acts directly on melanocytes to address the root cause by inhibiting tyrosinase activity, an enzyme that promotes new melanin synthesis.”
Hyperpigmentation is one of the main skin concerns of Asian skincare consumers and one of the earliest signs of aging for Asian women in their 20s.
“Asian skin is more susceptible to changes in pigmentation with age and is more prone to post-inflammatory hyperpigmentation, melasma, and freckles.”Mr. Charlton said.
Addressing hyperpigmentation is a difficult task due to its myriad complexities, and products on the market can be limited in addressing that complexity.
“Hyperpigmentation is a complex, multistep process, and melanin production is caused by a number of factors and regulatory mechanisms, which further influence the rate of melanin production, the transport and distribution of melanin to keratinocytes and other skin cells. This can complicate treatment because of the potential for side effects.” Mr. Charlton said.
“While some products inhibit the transfer of melanin to nearby skin cells, Dr. Ci:Labo products containing phenylethylresorcinol interfere with melanin production at its root cause by preventing the formation of hyperpigmentation.
“This product provides a holistic approach to combating melanin-related hyperpigmentation caused by external stressors and certain cosmetic procedures, improving collagen health as the foundation of healthy skin, and helping Asian women Achieve brighter, firmer, and more transparent skin.”
effective pairing
The data was presented by Kenvue at the American Academy of Dermatology (AAD) Annual Meeting in San Diego, California.
A new study addressed three major concerns in Asian skin: hyperpigmentation, aging skin, and sensitive skin.
“Our unique focus and deep understanding of the dermatological needs of Asian skin sets us apart in a field where such specialization is rare, and we are proud to serve Asian patients seeking skin care tailored to their individual needs. It has become a reliable brand for many people. ” Mr. Charlton said.
In addition to 377VC Radiance Serum, the latest data supported the efficacy and clinical validation of four additional Dr.Ci:Labo products.
These include Enrich Medica Lift Duo Serum, which integrates retinol and vitamin C derivatives in a biphasic formulation.
Twelve weeks of use demonstrated a 36.5% improvement in dermal collagen levels in Japanese women aged 45 to 55.
Additionally, it was shown to significantly increase the moisture content of the stratum corneum, improve skin elasticity, and reduce melanin.
“Retinol and vitamin C derivatives, while effective, are well known as delicate ingredients to incorporate because they are easily broken down. It is believed that formulating a one-phase serum is extremely difficult due to differences in sensitivity and stability conditions.” Charlton said.
Retinol and vitamin C are among the most popular ingredients in skin care due to their effectiveness and are trusted by dermatologists.
By incorporating these into a two-phase formulation, brands can “Overcome the challenge of keeping these sensitive ingredients in separate layers to maintain stability and potency”.
“The unique formulation not only ensures the stability of the vitamin C, but also maintains the effectiveness of the retinol as a whole. Also, because the active ingredients are stabilized, this product helps you get the full benefit of two active ingredients in one use.” Mr. Charlton said.
Further breakthroughs
Additionally, the company announced new data for Enrich Medica Lift Microneedle Serum and Retin 169 Serum.
The former showed that its unique microneedle system increases retinol absorption by 55.6%, resulting in a significant reduction in the appearance of wrinkles and improved skin elasticity.
Kenvue also showcased new data on its Retin 169 formula, which combines retinol and hexynol to amplify the effectiveness of retinol by 1.69x.
When combined, the cream and serum were found to reduce wrinkles around the forehead and mouth by 39.39% and 29.41%, respectively, over 24 weeks.
Skin sensitivity is also a growing concern among consumers in Asia, and the company has developed Aqua Collagen Super Sensitive products with Acetyl Hydroxyproline (AHP), which repairs and soothes the skin while restoring barrier function.
A 4-week study of 32 women found that this formulation significantly strengthened the skin’s barrier function, reducing redness by 5.91% and superficial skin blood perfusion by 6.22%.
Dr. Ci:Labo is a major derma skin care brand from Japan that came under the umbrella of Johnson & Johnson (J&J) after being acquired by Ci:z Holdings Co. in 2019.
Kenvue used to be a subsidiary of J&J, but spun off in 2023 to become a completely independent company.
The data presented by Dr.Ci:Labo at the American Academy of Dermatology Annual Meeting is not provided by Johnson & Johnson China Limited, JNTL Consumer Health Inc., and/or Johnson & Johnson Pte Ltd. Part of the project was sponsored by the company. Kenview’s.
Poster exhibitions will undergo a blind review by the Poster Exhibition Task Force, followed by a peer review scoring process. Accepted abstracts will be published online in the Journal of the American Academy of Dermatology (JAAD) supplement.
