From Scarlet Bee Balm (Monarda Didyma) is an aromatic herb from the Lamiaceae family native to eastern North America that contains large amounts of bioflavonoids such as didymium and isosacranetin. lemon balm (melissa officinalis) Contains as a technical process stabilizer.
“We tested several plant extracts for their activity in various cellular anti-aging markers, including epigenetic aging, telomere shortening rate, and mitochondrial ATP production,” says Mibel Biochemistry Foods & Co., Ltd. Head of Health Dr. Torsten Grote told NutIngredients. Bee balm extract showed the most promising results to date and was the only test sample to be effective in all three tests. ”
epigenetic age
Epigenetic age, as opposed to chronological age, refers to the biological age of an organism as determined by changes in DNA methylation patterns, histone modifications, and other epigenetic factors. This concept of biological age is increasingly attracting consumer attention.
“This has the potential to be a new megatrend, but so far only a small fraction of ingredients and consumer products, typically complex mixtures, have been studied at the clinical level,” Grote said. pointed out.
As consumer understanding of the category of healthy aging increases to include new claims such as rejuvenation, longevity, and delayed biological aging, Grote believes that “delaying biological aging is clinically “We expect the number of proven ingredients and supplements to increase rapidly.”
Age is being redefined in marketing, said Nick Morgan, director of Nutrition Integrated, which provides market and product data insights in a recent webinar titled “The Endless Possibilities of Eternal Youth.” said. Consumers are increasingly grappling with their chronological age and approaching aging as something that is adapted and influenced by nutrition and lifestyle.
“This all comes back to the fact that age is the last acceptable bias,” Morgan said. “This is like the final frontier of identity politics. Are we moving toward a time when age is fluid and self-defining, including gender and sexuality?”
Recent insights from James Brown, co-founder and director of nutrigenomics at epigenetic analysis company Muhdo, further highlight the growing consumer interest in this category.
“There seems to be a lot of interest in people actively trying to reduce the rate of aging, whether it’s in the form of supplements, certain types of diets, and/or our biohacks. There seems to be a lot of interest in people actively trying to reduce the rate of aging.” he said.
Researchers are currently studying genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, impaired macroautophagy, disordered nutrient sensing, mitochondrial dysfunction, cellular aging, stem cell depletion, cellular It takes into account 12 key features of aging, including changes in intercellular communication, chronic inflammation, and dysbiosis.
Unpublished studies conducted by Mibelle Biochemistry have shown that MonaJuventa Nu may affect eight markers, including mitochondrial ATP production, vascular function (by increasing nitric oxide release), and protection from oxidative stress. It has been.
Improved age markers
This study included one study that investigated the effects of Monajuventa Nu 100 mg on healthy aging in a group of 81 workers in stressful jobs between the ages of 45 and 65. It is.
Results showed improvements in key aging markers, leukocyte telomere length (LTL), quality of life (QOL), physical activity, and sleep compared to both initial conditions and placebo.
Further unpublished data from human fibroblast studies found a 40% reduction in epigenetic age. Results were evaluated using the Horvath Pan-Tissue Clock, which uses DNA methylation patterns to estimate biological age across different tissues.
“The epigenetic age of the untreated old cells was 29.96 years, while the age of the treated old cells was 18.59 years,” Grothe said. “This equates to a difference of 12 years for him, which in percentage terms (29.96 years = 100%) is a 40% reduction.
“At the molecular level, interactions with DNA-binding and DNA-modifying proteins, such as DNA methyltransferases, DNA demethylases, and transcription factors, are likely involved and require further investigation.”
