The following is a summary of “Decreased sensitivity to thyroid hormones is associated with decreased vitamin D levels in a euthyroid population” published in the March 2024 issue of the journal. endocrinology According to Lee et al.
For the study, researchers sought to investigate the relationship between vitamin D levels and thyroid hormone sensitivity in euthyroid individuals.
The study included 6,452 euthyroid participants and included clinical parameters such as TSH, free thyroxine, and 25-hydroxyvitamin D. [25(OH)D], and other relevant indicators were extracted from the National Health and Nutrition Examination Survey from 2007 to 2012. Thyroid hormone sensitivity was quantified using the Thyroid Feedback Quantile-Based Index (TFQI), TSH Index (TSHI), and Thyroid Stimulating Hormone Thyroxine Resistance Index (TT4RI).
People with impaired thyroid hormone sensitivity showed decreased 25(OH)D levels (TFQI, TT4RI: P < 0.05; Tushi: P = .05574), after adjusting for confounding variables. Analysis by age showed that there was a negative correlation between the thyroid hormone sensitivity index and 25(OH)D within the 20-60 year old subgroup, which shifted to a positive correlation in the 60-80 year old subgroup. has become clear. In women, thyroid hormone sensitivity index and vitamin D levels were negatively correlated, whereas in men, 25(OH)D levels above 63.5 nmol/L, 56.7 nmol/L, and 56.7 nmol/L The relationship changed from negative to positive. TFQI, TT4RI, and TSHI respectively. Stratification by race showed her U-shaped curve pattern similar to that observed in men. Subanalysis by body mass index (BMI) demonstrated mixed associations between vitamin D and thyroid hormone sensitivity index, with a negative association below 25 kg/m .2 30kg/m or more2 25-30 kg/m subgroup and U-shaped association2 subgroup.
Impaired thyroid hormone sensitivity is correlated with lower vitamin D levels in euthyroid subjects, and the association varies by age, sex, race, and BMI. The findings of this study highlighted the complex interplay between vitamin D and thyroid function and emphasized the importance of considering multiple demographic factors when evaluating their relationship.
reference: Academic.oup.com/jcem/article-abstract/109/3/691/7310986
