Senescent cell-derived vaccines: a source of specific antigens for cancer immunotherapy. Credit: aging (2024). DOI: 10.18632/aging.205975
A new review paper titled “Senogenic cell-derived vaccines: a new concept for immune responses against cancer and aging?” aging.
Two recent seminal studies have elucidated the complex role of tumor-associated senescent cells in cancer progression or regression by directing the immune system against cancer cells. The properties of these unique, yet diverse, cell populations must be considered, especially when considering the use of senolytics, drugs that selectively eliminate senescent cells, in cancer therapy.
In this new review, researchers João Pessoa, Sandrina Nóbrega Pereira and Bruno Bernardes de Jesus from the University of Aveiro discuss the current state of knowledge in the field.
“In particular, we discuss how the presence of senescent cells within tumors can be exploited as a therapeutic target in immunogenic cancers and how adaptive anti-senescence vaccines could hypothetically be designed,” the researchers wrote.
For more information:
João Pessoa et al. “Senogenic cell-derived vaccines: a new concept for immune responses against cancer and aging?” aging (2024). DOI: 10.18632/aging.205975
Provided by Impact Journals LLC
Quote: A review exploring the potential of senescent cell-derived vaccines against cancer and aging (July 1, 2024) Retrieved July 2, 2024 from https://medicalxpress.com/news/2024-07-explores-potential-senescent-cell-derived.html
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