The following is an abstract of the study “Effect of Vitamin D Supplementation on Muscle Function in Patients with Iodine-Induced Hypothyroidism: A Pilot Randomized Trial” published in the June 2024 issue of The Journal of Clinical Oncology. Endocrinology Maneewan et al.
There is limited data on the impact of vitamin D supplements on patients with I131-induced hypothyroidism. In the study, the researchers aimed to investigate the impact of vitamin D supplements on muscle function as the primary outcome and to observe secondary outcomes such as body composition, insulin resistance, and quality of life (QOL) in these patients.
In a pilot randomized placebo-controlled trial, patients with iodine-induced hypothyroidism receiving a stable dose of levothyroxine were enrolled and randomly assigned to receive oral vitamin D (20,000 IU weekly) or placebo for 24 weeks. Baseline biochemistry values, body composition, grip strength, 5-sit-to-stand test (5TSTS), homeostatic model assessment of insulin resistance (HOMA-IR), and quality of life were assessed before the intervention and after 3 and 6 months. Group outcomes were compared using mixed model regression analysis, with significant differences. P < .05.
Each group consisted of 20 participants. The time it took to complete the 5TSTS in the vitamin D group was significantly shorter than in the placebo group at 3 months (P = .032) and 6 months (P = .006). However, other outcomes, such as grip strength, body composition, HOMA-IR, and QOL, were not significantly different between the two groups.
Supplementation with vitamin D2 at 20,000 IU per week for 24 weeks improved 5TSTS performance in patients with I131-induced hypothyroidism.
reference: Academic Journals
