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Home » Can melatonin and other vitamins help with restless legs syndrome?
Vitamins & Supplements

Can melatonin and other vitamins help with restless legs syndrome?

theholisticadminBy theholisticadminMarch 7, 2024No Comments7 Mins Read
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If you suffer from restless legs syndrome, you know that it can be difficult to fall asleep and stay asleep.

Restless legs, also known as Willis-Ekbom disease, is a common neurological disorder that causes an uncontrollable urge to move your legs, caused by an involuntary kicking, itching, or crawling sensation in your lower body, according to the Mayo Clinic. This is a sleep and movement disorder. .

Are vitamins and supplements effective? Sleep medicine doctors who specialize in restless leg syndrome suggest that patients should tread carefully with these over-the-counter treatments.

“There’s a lot of support for iron, but little support for anything else. I’m wary of products that claim to help symptoms when nothing has been proven,” says the neurologist in Ann Arbor, Michigan. says J. Andrew Berkowski, M.D., physician and founder of ReLACS Health, a direct specialty practice. A care sleep clinic specializing in the management of complex sleep conditions, including restless legs syndrome.

“It may be effective in cases of mild restless legs syndrome, but if you are dealing with moderate or severe restless legs syndrome, it is unlikely to be ineffective,” says Dr. , added Dr. Brian Koo, director of the center. Yale University Medical Program for Restless Leg Syndrome in New Haven, CT.

What does the evidence say about these 5 vitamins for restless leg syndrome?

Here are the facts you need to know when trying these vitamins and considering supplements to help with restless legs syndrome (RLS).

1. Iron

Of all the supplements out there, iron should be your first choice for managing the symptoms of restless legs syndrome.

A study has found that iron deficiency in the brain may be the main cause of restless legs syndrome.

Dr. Burkowski says restless legs syndrome tends to be associated with several conditions that lower iron levels, including kidney disease, pregnancy, inflammatory conditions, and anemia.

Research published in frontiers of neurology in 2020 A study of 196 people with restless legs syndrome found that 42 percent were iron deficient, and those with iron deficiency tended to have poorer sleep.

Additionally, a 2019 review found that iron supplements improved the severity of restless legs syndrome symptoms compared to a placebo.

This is why treatment guidelines call for health care providers to test iron levels in patients with restless legs syndrome, Dr. Khoo said, adding that they typically continue to test patients’ iron levels even after diagnosis. .

But Burkowski says he wouldn’t recommend that patients take iron without consulting them. Treatment guidelines call for people who meet the criteria to take approximately 65 milligrams (mg) of iron on an empty stomach every 1 to 2 days, along with approximately 100 to 200 mg of vitamin C (vitamin C is (helps absorb iron).

Burkowski suggests it’s best to get iron naturally through your diet. Lean meat is the top source. “Not only does red meat contain the most iron, it’s also the best for your body to absorb.”

Other iron-rich foods include leafy greens, egg yolks, dried fruits, iron-fortified cereals and grains, turkey, beans, and lentils, according to the Harvard School of Public Health.

Related: Main food sources of vitamin C

2. Vitamin C and E

“Vitamin C increases iron absorption and helps reduce the effects of iron absorption inhibitors,” says Preeti Devnani, M.D., a staff physician at the Cleveland Clinic Sleep Disorders Center and a member of the American Academy of Sleep Medicine. says.

Treatment guidelines suggest that taking vitamin C and vitamin E together may be beneficial for patients with restless leg syndrome who are battling kidney failure.

(Restless legs syndrome occurs two to three times more often in people with kidney disease than in the general population.)

One trial found that a combination of vitamin C and vitamin E was safe and helped reduce the severity of restless leg syndrome symptoms in dialysis patients.

“Vitamins have been shown to have an effect on symptoms in patients with kidney failure, but this study has not been conducted in the general population,” said John Winkelman, M.D., professor of psychiatry and clinical director of sleep disorders at Harvard Medical School. To tell. Research program at Massachusetts General Hospital in Boston. Dr. Winkelman is a co-author of both sets of restless legs syndrome treatment guidelines mentioned above.

Related: Health benefits of vitamin C supplements

3. Magnesium

Magnesium is an essential mineral in the body and plays an important role in nerve and muscle function. According to the Cleveland Clinic, research shows it can help maintain a healthy sleep schedule.

But there isn’t enough recent research to suggest that magnesium supplements have additional benefits for people with restless leg syndrome, Winkelmann says (this is the conclusion of a treatment guideline he contributed to).

Dr. Devnani says there is anecdotal evidence that magnesium can help treat other types of leg cramps, but it doesn’t necessarily help treat restless leg syndrome. “We cannot draw any conclusions about the effectiveness of magnesium for restless legs syndrome or which specific patient groups may benefit,” she says of the evidence so far.

“We get asked about this a lot. Magnesium is often recommended, but there’s no evidence that it helps with restless leg syndrome,” says Burkowski.

Related: food sources of magnesium

4. Melatonin

Melatonin is a popular over-the-counter sleep aid that people use to treat insomnia, sleep disorders, jet lag, or simply to stay asleep. It’s also a natural hormone produced by the brain in response to darkness, which helps signal your body to sleep. To increase drowsiness and induce sleep, the supplement form should be taken approximately 30 minutes before bedtime.

Many Americans rely on melatonin for their sleep habits, but patients with restless leg syndrome should avoid melatonin. That’s because a study found that melatonin may increase leg movement in people with restless legs syndrome.

A small 2010 study of eight participants with severe restless leg syndrome found that taking 3 mg of melatonin in the evening significantly increased leg movement.

Melatonin helps with circadian sleep disorders such as jet lag and shift work disorder, but restless leg syndrome is a movement disorder, Berkowski points out.

Related: Melatonin mistakes sleep doctors want to avoid

5. Vitamin D

Early research suggests that supplements may help sleep for people with restless leg syndrome who have vitamin D deficiency. But experts warn there is not yet enough evidence to widely recommend it to patients.

2022 small studies published in journals Frontiers of endocrinology We found a link between vitamin D deficiency and poor sleep quality in people with restless legs syndrome.

Another study published in 2023 Tremors and other sudden movements They report that patients with restless legs syndrome may be deficient in vitamin D and may benefit from vitamin D supplements.

Still, Burkowski says there isn’t enough evidence yet for sleep experts to recommend vitamin D supplements as a treatment option. “This needs further testing as there is no convincing mechanism as to why it works,” he says.

Related: What is the recommended intake of vitamin D?

Bottom line: Should you consider supplements to help with restless legs syndrome?

First and foremost, Koo, Berkowski and Winkelmann say people with restless legs syndrome should work with their doctors to discuss lifestyle changes and treatment options that can help manage their symptoms. do.

Winkelmann said that while there is evidence that some supplements may play a role in symptom management, there is not yet enough evidence to broadly recommend them to all patients.

“Given that we have many effective approaches that work, we shouldn’t tell people who are really suffering to try[vitamins or supplements]without evidence that they will help.” Winkelmann says. However, getting enough of these vitamins in your diet is a wise move to avoid deficiencies.

Evidence-backed treatment options for restless legs syndrome include:

  • Lifestyle changes Burkowski says avoiding alcohol, caffeine and tobacco can help manage symptoms. Sitting still for long periods of time can trigger the symptoms of restless legs syndrome, so it’s a good idea to make time to exercise each day.
  • antiepileptic drug Drugs such as gabapentin (Neurontin, Horizant) and pregabalin (Lyrica) are often the first-line treatment. It relieves both leg discomfort and nerve pain.
  • dopamine agonist The U.S. Food and Drug Administration (FDA) has approved several options to treat moderate to severe restless legs syndrome, including ropinirole (Requip), pramipexole (Mirapex), and rotigotine (Neupro).
  • opioid Opioids are a type of drug used to relieve pain, but they carry the risk of addiction. It may be used to treat severe restless leg syndrome symptoms when other drugs do not improve symptoms. Examples include codeine, oxycodone, and hydrocodone.



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