Increased serum levels of 25-hydroxyvitamin D (25[OH]D) is independently associated with a lower risk of bowel resection for inflammatory bowel disease (IBD), according to a study published online on March 25. International Journal of Surgery.
Lingtao Dan and his colleagues at the Third Xiangya Hospital of Central South University in Changsha, China, investigated the association between serum vitamin D levels and the risk of intestinal resection in patients with IBD. The analysis included 5,474 patients with IBD who were followed for an average of 13.1 years.
Researchers found that compared to participants with vitamin D deficiency, non-deficiency participants had a significantly reduced risk of bowel resection (hazard ratio) in IBD. [HR]0.72), Crohn’s disease (CD; HR, 0.74), and ulcerative colitis (UC; HR, 0.73).
The highest and lowest quintiles of 25(OH)D levels had a 34% reduced risk of bowel resection due to IBD and a 46% reduced risk of UC. These findings were statistically significant. However, there was no significant association with the risk of bowel resection in CD. Using a restricted cubic spline curve, a linear dose-response relationship was seen.
“Vitamin D deficiency is a risk factor for intestinal resection in patients with IBD and may be a useful indicator in predicting surgical events and risk screening,” the authors wrote.
For more information:
Lintao Dan et al., Circulating 25-hydroxyvitamin D concentrations can predict intestinal resection risk in patients with inflammatory bowel disease in a longitudinal cohort with 13 years of follow-up. International Journal of Surgery (2024). DOI: 10.1097/JS9.0000000000001369
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